![]() This report will also discuss the history of dietary management and acute and chronic complications of diabetes. ![]() Trials to prepare an orally administrated hypoglycemic agent ended successfully by first marketing of tolbutamide and carbutamide in 1955. Later, this discovery constituted the basis of insulin isolation and clinical use by Banting and Best (Canada) in 1921. The role of the pancreas in pathogenesis of diabetes was discovered by Mering and Minkowski (Austria) 1889. An important milestone in the history of diabetes is the establishment of the role of the liver in glycogenesis, and the concept that diabetes is due to excess glucose production Claude Bernard (France) in 1857. In modern time, the history of diabetes coincided with the emergence of experimental medicine. It was only in 1776 that Dobson (Britain) firstly confirmed the presence of excess sugar in urine and blood as a cause of their sweetness. ![]() ![]() Later, the word mellitus (honey sweet) was added by Thomas Willis (Britain) in 1675 after rediscovering the sweetness of urine and blood of patients (first noticed by the ancient Indians). The Philatelic History of Diabetes by Lee J. The term "diabetes" was first coined by Araetus of Cappodocia (81-133AD). ![]() Clinical features similar to diabetes mellitus were described 3000 years ago by the ancient Egyptians. ![]()
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